【摘要】 目的　探讨高氧液对新生儿缺血缺氧性疾病治疗的可行性及疗效。方法　采用比色法、血气分析检测 2 0例用高氧液患儿血浆SOD、MDA及血气变化 ,同时以 2 0例未用高氧液患儿作对照 ,观察临床症状、体征改变。结果　用高氧液组PaO2 、SaO2 明显升高 (P <0 .0 1) ,PaCO2 明显下降 (P <0 .0 1) ,同时有pH、HCO3 -、BE下降 ;血浆SOD升高、MDA下降 (P <0 .0 1) ;用高氧液临床症状体征迅速改善 ,有效率 95 % (P <0 .0 5 )。结论　高氧液对治疗新生儿缺血缺氧性疾病尤其是低氧血症有明显效果更多还原

【Abstract】 Objective To investigate the protective effect of hyperoxia liquid on neonatal hypoxic-ischemic diseases. Methods Forty newborn infants were divided randomly into two groups: control group receiving the routine treatment after hypoxia and ischemia and treatmemt group receiving the routine treatment and infusion of hyperoxia liquid 10 ml·kg -1 after hypoxia and ischemia. Results In treatment group, after giving hyperoxia liquid, PaO 2, SaO 2, and plasma SOD activity were obviously higher than before (P< 0.05). PaO 2, pH, HCO 3 -, BE and plasma MDA content were significantly lower than before (P<0.01). The clinical manifestation of treatment group improved more rapidly than that of control group. Conclusion ① Hyperoxia liquid has obvious protective effects on hypoxic-ischemic disease in newborn infants. ② The application of hyperoxia liquid needs to be improved and developed.更多还原