【摘要】 目的 :测定六神丸及各单味药中可溶性砷的含量及砷与半胱氨酸配合作用和毒性关系。方法 :DDC -Ag方法测定可溶性砷的含量。用化学模拟法合成砷—半胱氨酸配合物。结果 :六神丸中砷回归方程为Y =0 0 0 36± 0 3110 ,r =0 9994。得到半胱氨酸砷配合物 ,毒性实验结果 :三氧化二砷LD50 =15 0mg/kg ,半胱氨酸砷配合物LD50 =6 5 0mg/kg。结论 :六神丸和雄黄含砷外 ,个别单味药也含有微量砷。这与多方面因素有关。砷能与半胱氨酸发生配合作用 ,形成半胱氨酸砷配合物。急毒实验证明配合物的毒性明显低于三氧化二砷的毒性。说明半胱氨酸能拮抗砷的毒性更多还原

【Abstract】 Objective: The determination of soluble arseniic in the Liu Shen Wan and each in Chinese Medicinal Herbs, synthesis of cysteine—arsenic(Ⅲ) complex. Method: The contents of soluble arsenic have been determined with DDC-Ag method. chemosythesis of cysteine-arsenic(Ⅲ) complex. Result: Cysteine-arsenic(Ⅲ) complex were obtained. Toxicology As 2O 3 LD 50 =150 mg/kg, cysteine-arsenic(Ⅲ) complex LD 50 =650 mg/kg. Condusion: The contents of trace arsenic except of Liu Shen Wan and realagr, each one in Chinese Medicinal Herbs too contentstrace arsenic. The complex of cysteine—arsenic(Ⅲ) is sythcisized. The results of toxicooology showed that toxic of complex expressly is lower than that in As 2O 3. The results showed that cysteine antagonsim of toxic of arsenic.更多还原