【摘要】 采用双扩散法研究了凝胶体系中四元羧酸盐(Na2EDTA)、三元羧酸盐柠檬酸钠(Na3cit)、二元羧酸盐酒石酸钠(Na2tart)和一元羧酸盐醋酸钠(NaAc)对草酸钙(CaOx)结晶的影响.抑制一水草酸钙(COM)聚集的能力为:Na2EDTA>Na3cit>Na2tart>NaAc;诱导二水草酸钙(COD)的能力为:Na3cit>Na2tart>Na2EDTA>NaAc.羧酸的抗衡阳离子影响CaOx的结晶.H3cit、Na3cit和K3cit抑制COM聚集和诱导COD形成的能力均为:K3citNa3cit>H3cit.无论是诱导COD生成,还是抑制COM聚集,均可以减小结石形成的几率,对临床上防治结石具有积极的意义.更多还原

【Abstract】 The effects of structurally specific carboxylates on the crystallization of calcium oxalate(CaOx) were investigated in gel by a double diffusion technique. The ability to inhibit the aggregation of calcium oxalate monohydrate(COM) follows the sequence: tetracarboxylate(Na2EDTA) >tricarboxylate(sodium citrate) > dicarboxylate(sodium tartrate) >monocarboxylate(NaAc). The ability to induce calcium oxalate dihydrate(COD) follows the order: sodium citrate >sodium tartrate >Na2EDTA >NaAc. The counterions of carboxylic acids affected the crystallization of CaOx. The ability of both inhibiting the aggregation of COM and inducing the formation of COD follows the sequence: potassium citrate sodium citrate >citric acid. Both inhibiting the aggregation of COM and inducing the formation of COD can decrease the probability of the formation of urinary stones. These results may have positive significance in the prevention and cure of urinary stones.更多还原