【摘要】 目的:本实验通过对直肠癌预后影响因素的回顾性研究,探索肿瘤预后参数与它们间关系的依据。方法:通过免疫组化技术检测43例直肠癌病人的增殖细胞核抗原(PCNA)的表达和微血管定量分析(MVC)。结果:研究发现MVC和PCNA的表达与肿瘤不同的分化程度、浸润深度、临床分期和生存时间以及是否有淋巴结转移和远处转移之间均有显著性相关(P<0.05)。应用Cox比率风险模型进行分析,浸润深度、淋巴结转移和MVC的表达均是独立的预后因素。结论:MVC、PCNA的表达与直肠癌浸润、淋巴结转移、远处转移有关,其中MVC的表达、浸润深度和淋巴结转移均是独立的有意义的预后因子,可作为预期直肠癌总体生存率的重要参数。更多还原

【Abstract】 Objective: To investigate microvessel count (MVC) and proliferating cell nuclear antigen (PCNA) in rectal cancer and their relationships with metastasis and recurrence. Methods: The paraffin blocks of 43 patients with rectal cancers removed by low anterior or abdominoperineal resection between 1990 and 1993 were recalled and immunostained with monoclonal antibody specific for FⅧ-RAg and PC10. Results: Both Indexes of MVC and PCNA were significantly correlated with differentiation (P<0.05), depth of infiltration (P<0.05), lymph node or liver metastasis (P<0.05), clinical stages (Astler-Coller stage) (P<0.05) and prognosis (P<0.05). Proportional hazards regression model shown both indexes were independent predictors. Conclusions: MVC and PCNA, as defined by FⅧ-Rag and PCNA immunohistochemical analysis, were related with differentiation, depth of invasion, metastasis of rectal carcinoma. It also indicates that they may be helpful as predictors of long-term survival and in planning prophylactic adjutant therapy.更多还原