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肿瘤受体显像剂99Tcm-octreotide的放化纯度分析

The Analytical of Radiochemical Purity of Tumor Receptor Imaging Agent 99Tcm-octreotide

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【作者】 王叙馥左书耀邵文博王国明孙建文张勤

【Author】 WANG Xu-fu, ZUO Shu-yao, SHAO Wen-bo, WANG Guo-ming,SUN Jian-wen,ZHANG Qin(Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China)

【机构】 青岛大学医学院附属医院核医学科青岛大学医学院附属医院核医学科 山东 青岛 266003山东 青岛 266003山东 青岛 266003

【摘要】 采用高压液相色谱分析(HPLC)和双层析结合银染色两种方法,对新型肿瘤受体显像剂99Tcm-oc-treotide的放化纯度进行分析。结果表明,双层析法结合银染色可以准确、有效地分离99Tcm-octreotide及其它放射性组分,可以较精确地计算出显像剂的放化纯度。为Octreotide及其它多肽类显像剂的放化纯度测定提供了一种简捷、准确的新手段。

【Abstract】 The radiochemical purity of tumor receptor imaging agent 99Tcm-octreotide is measured by High Pressure Liquid Chromatography (HPLC) and two systems of chromatography combining method of silver stain. The results show that the radiochemical purity of 99Tcm-octreotide measured by both methods are effective and correct. It can separate 99Tcm-octreotide from other radioactive compositions correctly and effectively.

  • 【分类号】R917
  • 【被引频次】2
  • 【下载频次】59
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