【摘要】 目的　研究t PA基因h( 8th)内含子的Alu重复序列插入 缺失 (I D)多态性在脑栓塞患者中的分布。方法　提取 16例患者口腔黏膜脱落细胞DNA ,应用PCR方法扩增t PA基因h( 8th)内含子的Alu重复序列 ,记录Alu插入 缺失 (I D)结果。结果　 16例患者中插入纯和 6例 ,缺失纯和 6例 ,插入 缺失 4例 ;插入纯和 (I I)率是缺失纯和 (D D)的 1 0倍 ;(I I)和 (I D)的几率之和约是 (D D)的 1 6 7倍。结论　脑栓塞患者t PA基因h( 8th)内含子的Alu重复序列插入 缺失 (I D)与大样本山东人t PA Alu插入 缺失率不同。更多还原

【Abstract】 Objective: To investigate the allelic distribution of Alu repeat in tissue type plasminogen activator (t PA) gene loci of cerebral infarction patients Methods: Genome DNA was isolated from the buccal cells of 16 patients The 8th intron of t PA was analysed by polymerase chain reaction, which resulted in three different genotype homology of insertion(I/I) or deletion(D/D) and heterology of insertion and deletion(I/D) Results: 6 I/I, 6 D/D and 4 I/D were detected Conclusion: The t PA Alu polymorphism of cerebral infarction patients differs from that of the control which we found out on a large scale research更多还原