【摘要】 探讨重症肝炎甲胎蛋白 (AFP)测定的临床意义。方法　分析 112例重症肝炎病人AFP水平及其变化与患者预后的关系。结果　 112例重症肝炎中 ,急性重症肝炎 18例 ,亚急性重症肝炎 19例 ,慢性重症肝炎 75例。其中 4 7例AFP <2 0 μg/L(A组 ) ,死亡 4 0例 ,治愈好转 7例 ;2 4例 2 0 μg/L≤AFP <10 0 μg/L(B组 ) ,死亡 16例 ,治愈好转 8例 ;2 2例 10 0 μg/L≤AFP <4 0 0 μg/L(C组 ) ,死亡 6例 ,治愈好转 16例。 19例AFP≥ 4 0 0 μg/L(D组 ) ,死亡 4例 ,治愈好转 15例。A组与B组、C组与D组总死亡率无显著差异 (P >0 0 5 ) ,A组与C组、A组与D组、B组与C组、B组与D组间总死亡率有非常显著的差异 (P <0 0 5～P <0 0 1)。结论　AFP水平与重症肝炎的预后有关 ,可作为判断重症肝炎预后的指标之一更多还原

【Abstract】 Objective: To explore the clinical significance of the detection of alpha fetoprotein (AFP) in hepatitis gravis Methods: The relationship between AFP levels, differentiations in them and the prognosis was analyzed in 112 patients with hepatitis gravis Results: Of the 112 cases, 18 were acute hepatitis gravis, 19 subacute hepatitis gravis, and 75 chronic hepatitis gravis There were 40 deaths and 7 recoveries in the 47 cases with AFP<20 μg/L(Group A); 16 deaths and 8 recoveries in the 24 cases with 20≤AFP<100 μg/L (Group B); 6 deaths and 16 recoveries in the 22 cases with 100 μg≤AFP<400 μg/L (Group C); 4 deaths and 15 recoveries in the 19 cases with AFP≥400 μg (Group D) There was no significant difference between Group A and Group B, or Group C and Group D in the total mortality (P>0 05), but there were significant differences between Group A and Group C, Group A and Group D, Group B and Group C, and Group B and Group D in the total mortality (P<0 05～P<0 01) Conclusion: The level of AFP is related with the prognosis of hepatitis gravis and can be an index of hepatitis gravis更多还原