【摘要】 [目的]观察合成冰片是否有诱发沙门氏菌株发生基因突变的作用。[方法]采用鼠伤寒沙门氏菌营养缺陷型回复突变试验(Ames试验)。[结果]合成冰片在0.4～250μg/皿范围内 ,无论有或无肝脏微粒体酶(S9)活化系统 ,对菌落回变无明显影响 ,且回变菌落背景正常。[结论]合成冰片对鼠伤寒沙门氏菌突变株无致突变作用 ,具有临床应用的安全性更多还原

【Abstract】 To observe the mutagenicity effect of Synthetic Borneol. Ames test was used. The number of backward mutant colony of four bacterial strains induced by Synthetic Borneol at the concentration within 0.4～250 μg/plate was quantified. The results did not display a significant increase compared with that induced by dimethylsulfoxide, whether with metabolic activation system (S9_mix) or not. Moreover, the backward mutant colony had normal background. [Conclusion] Synthetic Borneol did not possess evident mutagenicity through our study.更多还原