【摘要】 [目的]探讨清热化滞颗粒对胃泌素、血管活性肠肽的影响。[方法]采用放射免疫分析法同步测定积滞模型小鼠自然恢复组、灌喂清热化滞颗粒组和空白对照组小鼠血浆和小肠组织胃泌素 (GAS)、血管活性肠肽 (VIP)的水平。[结果]模型建成后 ,小鼠血浆和小肠组织胃泌素含量降低 ;小肠组织VIP的含量增加。灌喂清热化滞颗粒后GAS增加 ,与模型组比较有显著性差异 ;VIP无明显变化。[结论]清热化滞颗粒治疗小儿积滞化热证的作用机制可能与其调节胃肠激素 ,促进胃肠蠕动有关更多还原

【Abstract】 To explore the influence of Qingre Huazhi Granule(clearing away the heat and removing the food stagnation)on gastrin(GAS)and vasoactive intestinal peptide(VIP)in mouse with heat due to food stagnation. The content of GAS and VIP in plasma and the tissue of small intestine of each group were detected by radioimmunoassay simultaneously.In model group the content of GAS was lower in plasma and small intestine tissue and VIP in small intestine tissue increased.After treatment with Qingre Huazhi Granule GAS but VIP,was increased with an obvious difˉference with that in model group.[Conclusion]The mechanism of Qingre Huazhi Granule treating pediatric food stagnation is associated with modulation of GAS secretion and improvement of gastrointestinal peristalsis.更多还原