【摘要】 目的 :研究人类白细胞抗原 -DQA1(HLA -DQA1)等位基因与儿童Graves病 (GD)的相关性。方法:采用聚合酶链反应 -限制性片段长度多态性 (PCR -RFLP)基因分型技术对24例GD患儿及51例正常儿童对照进行了HLA -DQA1基因分型并分析其相关性。结果 :GD组HLA -DQA10201等位基因频率 (GF)明显低于正常对照组 (RR=0.09,P<0.01)。结论 :HLADQA10201可能是儿童GD的一个保护等位基因更多还原

【Abstract】 Objective:To study the correlation between Graves’disease(GD)in children and HLA-DQA1alleles.Methods:The allelic types of HLA-DQA1were detected by polymerase chain reaction-restriction fragment length polimorphism(PCR-RFLP)technique in24children with GD and51normal children.Results:The frequency of HLA-DQA10201was significantly decreased in GD group(2.08%vs18.63%,RR=0.09,P<0.01).Conclusion:HLA-DQA10201may be a defensive gene in GD.更多还原