【摘要】 目的　观察中药喷雾剂治疗复发性口腔溃疡的临床疗效 ,并检测治疗前后血清免疫学、肿瘤坏死因子α(TNF α)、白细胞介素 1(IL 1)水平的变化。方法　对 34例口腔、舌体溃疡患者将中药喷雾剂用德国产百瑞压缩雾化吸入机喷雾治疗 ,5d为一疗程 ,并与 2 1例对照组进行比较。治疗前后进行血清免疫学检测 ,采用放射免疫分析法检测TNF α、IL 1水平变化。结果　治疗组总有效率 88 3% ,对照组为 5 2 4 % (P <0 0 1)。治疗后与治疗前的TNF α、IL 1比较差异均有显著性意义 (均为P <0 0 5 ) ,治疗组与对照组比较差异有显著性意义 (P <0 0 1)。结论　口腔粘膜、舌体溃疡早期TNF α、IL 1水平均有升高 ,治疗后随溃疡愈合而下降 ,但血清免疫学无明显变化。中药喷雾剂具有清泄心、胃之火 ,清热解毒 ,消炎止痛 ,促愈敛疡的作用 ,且疗效确切 ,价格低廉 ,使用方便 ,无副作用。更多还原

【Abstract】 Objective To observe the clinical effect of the spray made from Chinese medical herbs on recurrent oral ulcer, and to measure serum immunologicl figures, TNF α, IL 1 before and after therapies. Methods 34 patients with oral ulcer were treated with the spray of Chinese medical herbs from Germany PARI compressive nebuliser for 5 days and compared with 21 controls. Serum immunological figures were determined and the levels of TNF α and IL 1 were measured by immunofluoscence. Results The total effective rate in the treated group and control group was 88 3 % and 52 4 % respectively ( P <0 01). There was significant difference in serum TNF α and IL 1 before and after therapy ( P <0 05) or between the treated group and control group ( P <0 01). Conclusion Serum TNF α and IL 1 both increased in the early stage of oral ulcer and decreased after the treatment with the healing of the ulcer. However, serum immunological figures were not changed before and after the treatment. Chinese medical herbs aerosol inhalation could clear heart and gastric fire, expel toxin, clear heat, regenerate tissue and promote the ulcer healing. It is effective, convenient to treat oral ulcer and has no side effect.更多还原