【摘要】 目的 :建立测定卡铂栓溶出度的实验方法 ,提供药品评价和质控的依据。方法 :溶出度的测定采用比色法 ,水平滚筒溶出装置 ,蒸馏水 ( p H 5～ 7)为溶出介质。结果 :卡铂栓剂溶出度 5小时为 6 5 %以上 ,6小时为 80 %以上。结论 :此方法准确、快速、简便。为控制卡铂栓的质量 ,有必要进行溶出度测定更多还原

【Abstract】 Object: To establish a method for determining the dissolution rates of carpolatine in suppository and provided a basis for drug appraisal and quality control. Methods: The dissolution rate was determined by colorimetry with the level roll dissolution instrument and water (pH 5-7) as dissolution medium. Results: The dissolution of carpolatine in suppository after 4 and 6 hours were 65% and 80%, respectively. Conclusion: The method is simple, rapid and accurate. It is necessary to determine the dissolution for quality control.更多还原