【摘要】 目的　探讨脂肪肝患者多项血清肝纤维化指标和总胆汁酸联合检测及其临床意义。方法　用放免法和速率散射比浊法测定 2 8例正常人和 4 3例脂肪肝患者的血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (Ⅳ C)、层粘蛋白 (LN)和总胆汁酸 (TBA)。结果　HA、PCⅢ、Ⅳ C、LN和TBA随脂肪肝患者肝纤维化程度而增高 (P <0 .0 1～ 0 .0 5 ) ,HA和TAB指标的变化与γ球蛋白、A/G显著相关 (P <0 .0 5 )。结论　测定血清HA、PCⅢ、Ⅳ C、LN和TBA水平对脂肪肝有一定的诊断和判断预后价值 ,其中 ,HA和TAB最敏感更多还原

【Abstract】 Objective To investigate the clinical signifi ca nce of associated determine of serum hepatic fibrosis items and total bile acid levers for Fatty liver patients.Methods The serum hyaluronic acid(HA),procollagen type Ⅲ (PCⅢ),collage type Ⅳ(Ⅳ-C),laminin(LN) and total bile acid(TAB) were determ ined in 43 cases of fatty liver diseases and 28 normal subjects by means of RIA and rate nephelometry.Results The serum HA,PCⅢ,Ⅳ-C,LN and TAB increased w ith the severity of fatty liver ( P <0.01～0.05), The HA and TAB items were correlated with γ globulin and A/G( P < 0.05 ).Conclusion To determine serum levels of HA,PCⅢ,Ⅳ-C,LN and TAB is definite value of diagnosis and prognosis for fatty liver and HA and TAB is the most sensitive of the five items.更多还原