【摘要】 目的　观察肝硬化患者降钙素基因相关肽 (calcitoningene relatedpeptide ,CGRP)和肿瘤坏死因子 α(tumornecrosisfactor α,TNF α)血浆浓度变化 ,并探讨其临床意义。方法　放射免疫法测定 42例肝硬化患者和 2 6例正常人血浆CGRP和TNF α的浓度。结果　血浆CGRP和TNF α的浓度肝硬化组明显高于正常对照组 ,肝功能Chil dA、B、C级各组中浓度依次升高。血浆CGRP和TNF α间存在明显正相关。腹水组血浆CGRP和TNF α的浓度明显高于无腹水组。结论　血浆CGRP和TNF α的浓度反映肝硬化严重程度 ,门脉高压腹水形成时明显升高。血浆CGRP和TNF α可能在肝硬化发展过程中起一定作用。更多还原

【Abstract】 Objective To study the levels of the alteration of calcitonin gene-related peptide (CGRP) and tumor necrosis factor-α(TNF?α) in cirrhotic patients and to assess its clinical significance.Methods Plasma levels of CGRP and TNF?α were measured in 42 cirrhotics and 26 healthy subjects by radio-immunological method.Results Cirrhosis group showed significantly higher plasma CGRP and TNF?α levels than those in the control group.In cirrhosis with hepatic function impairment,plasma levels of CGRP and TNF?α increased,the degree of increasing being in the order of Child’s A,B,C classification.Plasma CGRP correlated significantly with plasma TNF?α in cirrhosis.Plasma CGRP and TNF?α levels in cirrhosis with ascites were higher than those without ascites.Conclusion The levels of plasma CGRP and TNF?α increase with the severity of cirrhosis. They are significantly higher in cirrhosis with ascites.CGRP and TNF?α may play an important role in the progress of cirrhosis.更多还原