【摘要】 建立了分离头孢克洛和δ_3头孢克洛的毛细管区带电泳法 （CZE） ;在CZE中 ,以4_磺酸杯芳烃[6]作为异构体选择性试剂成功地分离了头孢克洛和δ_3头孢克洛 ;当以4_磺酸杯芳烃[6]作为异构体选择性试剂时 ,背景缓冲液的pH值和4_磺酸杯芳烃[6]的浓度是影响头孢克洛和δ_3头孢克洛分离的重要参数 ;同时还考察了有机溶剂和 β_环糊精对分离的影响 ;并将该方法成功地用于测定口服头孢克洛干混悬剂中的有效成分———头孢克洛 ,结果令人满意更多还原

【Abstract】 A method,capillary zone electrophoresis,for the separation of cefaclor andδ_3cefaclor was deve loped.In the method,4_sulfonic calixarene（SCX6）was used as an isomer separating agent.The concentration of SCX6and pH of the background buffer were found to be important parameters in the separation of cefaclor andδ_3cefaclor.The influences of organic modifiers andβ_cyclodextrin on the separation were also investigated.The method was applied to separate and determine active ingredient in cefaclor for oral dry suspension successfully.更多还原