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高效液相色谱法测定心脉素注射液中20（S）-人参皂苷Rg₂和20（R）-人参皂苷Rg₂构型异构体的含量

The Content Determination Simultaneously of Isomer 20（S）- & 20（R） - Ginsenoside Rg₂ in Xinmaisu Injection by Rp - HPLC

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【Author】 DONG Hong-bo, PAN Shu-yang, WU Ping, ZHANG Min, LI Chao-sheng(Pharmaceutical College of Jilin University. Changchun,Jilin 130021; Jilin Provincial Institude for Drug Control.Changchun,Jilin 130062; Department of Pharmacology,Academy of Traditional ChineseMedicine of Jilin Province, changchun, Jilin 130021)

【机构】吉林大学药学院；吉林省药品检验所；吉林省中医中药研究院吉林长春 130021；吉林长春 130062；吉林长春 130021；

【摘要】建立心脉素注射液中20（S）-人参皂苷Rg₂和20（R）-人参皂苷Rg₂构型异构体的高效液相色谱测定法。采用YWG—C₁₈分析柱,以甲醇-磷酸溶液（1→25）（7:3）为流动相,在203nm波长处检测。平均回收率分别为99.5％和100.6％。相对标准偏差分别为1.2％和1.4％。该方法准确、简便。更多还原

【Abstract】 A Rp- HPLC method was described for the determination of isomer 20(S) &20(R) - ginsenoside Rg2. Xinmais Injecticn The sample solution can be injected into a system comprising a column(4. 6mmID×25cm) of YWG-C18 with methanol-H3PO4(1→25)(7:3) as mobile phase and a detection wavelength at 203nm. The average recovery was 99.53% and 100. 6% ,and RSD were 1. 2% and 1.4%,respectively. The method was accurate and simple.更多还原