【摘要】 目的 探讨组织金属蛋白酶抑制剂-2(TIMP-2)表达与大肠癌浸润转移的关系。方法 采用S-P免疫组织化学染色技术,检测30例大肠腺瘤,60例大肠癌组织TIMP-2的表达情况。结果 TIMP-2的表达在大肠腺瘤和大肠癌组织中没有显著性差异(P>0.05);但其表达与大肠癌的Dukes分期、淋巴结转移、远隔脏器转移及生存期均有关(P<0.05)。结论TIMP-2的检测可以成为临床判断大肠癌的恶性程度、转移及预后的重要参考指标。更多还原

【Abstract】 Objective To investigate the role of the expressionof Tissue inhibitor of metalloproteinase-2 (TIMP-2) in invasion andme-tastasis of colorectal cancer( CRC) . Methods The TIMP-2 expression was studied immuneohistochemistrically in 30 specimens of color-ectaladenoma and 60 specimens of CRC. Results No apparent correlation was observed between the expression of TIMP-2 and colorectal adenoma and CRC ( P > 0.05), Significant relationship was observed between low TIMP-2 expression and Dukes stage, metastasis of lymph node anddistant organs and poor prognosis. Conclusion The detection of expression about TIMP-2 may be helpful to judge the malignant behavior, metastasis andprognosis with colorectal carcinoma.更多还原