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正交设计研究补骨脂中总黄酮提取工艺

Studies on the process for extraction of Psoralea corylifolia L. by orthogonal experiments

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【作者】 许勇郭兴杰范捷李发美

【Author】 XU Yong 1, GUO Xing-jie 1, FAN Jie 2, LI Fa-mei 1 (1.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2.The Centeral Hospital of Huludao, Huludao 125001, China)

【机构】 沈阳药科大学药学院葫芦岛市中心医院沈阳药科大学药学院 辽宁沈阳110016辽宁沈阳110016辽宁葫芦岛125001辽宁沈阳110016

【摘要】 目的优选补骨脂最佳提取工艺。方法采用正交实验法 ,以提取液中总黄酮含量为考察指标 ,对影响总黄酮提取工艺的因素进行了研究。结果实验设计三因素中乙醇浓度有显著影响。结论补骨脂的最佳提取工艺为A3B2 C2 ,即用 1 0倍量 2 1mol L乙醇回流 3次 ,每次 2h。

【Abstract】 Objective To optimize the conditions for the extraction of Psoralea corylifolia L..Methods The conditions for the extraction were studied by the orthogonal experimental design as guided by the content of total flavonoids present in the extract.Results A significant effect was observed in the concentration of alcohol. Conclusions The optimum conditions for the extraction of Psoralea corylifolia is A 3B 2C 2,that is,adding ten times the amount of 95% alcohol and refluxing and extracting for 2h(totally extracting 3 times).

  • 【文献出处】 沈阳药科大学学报 ,Journal of Shenyang Pharmaceutical University , 编辑部邮箱 ,2003年02期
  • 【分类号】TQ461
  • 【被引频次】42
  • 【下载频次】661
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