【摘要】 目的　探讨急性胰腺炎患者血浆vW因子的变化及其临床意义。方法　采用双抗体夹心固相酶免疫法测定 3 5例急性胰腺炎患者和 3 0名健康献血者的血浆vW因子水平 ,对其进行相关性分析。结果　急性胰腺炎患者入院后 2 4h血浆vW因子水平为 2 15 .0 %± 2 3 .4% ,显著高于正常对照组 10 7.5 %± 2 9.6% (P <0 .0 0 1) ;重症急性胰腺炎患者血浆vW因子显著高于轻型急性胰腺炎患者 (P <0 .0 1) ;血浆vW因子预测重症AP的敏感性、特异性和准确性分别是 91.7%、87.0 %和 88.7%。结论　急性胰腺炎患者存在血管内皮损伤 ;测定急性胰腺炎患者血浆vW因子水平可早期预测病情的严重程度更多还原

【Abstract】 Objective To investigate the clinical significance of plasma von Willebrand factor (vWF) in acute pancreatitis (AP).Methods The plasma levels of vWF were measured in 35 cases of AP by the dual radiolabeled monoclonal antibody technique of 1,3 and 5 days after admission.Results The plasma levels of vWF in patientes with AP significantly increased in comparison with normal subjects (215.0±23.4)% Vs (107.5±29.6)% ( P <0.001).The plasma levels of vWF in severe AP significantly increased in comparison with mild AP(251.9±22.7%) Vs (196.6±25.5)% ( P <0.01).The sensitivity,specifity and efficiency were 91.7%,87.0% and 88.7% for vWF in assessing the severity of pancreatitis.Conclusions vWF may reflect the vascular endothelial injury.The plasma levels of vWF may predict the severity of AP at early stage.更多还原