【摘要】 目的　探讨血、尿微球蛋白测定对老年 (≥ 6 0岁 )原发性高血压 (EH)患者肾损害诊断的敏感性。　方法　将 76例EH患者按年龄是否≥或 <6 0岁分为两个亚组 ,另选健康体检者 2 8例作为正常对照 ,取空腹血 3ml,晨尿 3ml。用同位素放射免疫法测定血、尿α1 微球蛋白及 β2 微球蛋白的含量。　结果　EH患者中两组血清α1 微球蛋白明显高于正常对照组 (分别P <0 0 5和 <0 0 1) ,而血清 β2 微球蛋白在老年组升高明显 (P <0 0 5 ) ;EH患者中两组尿液α1 微球蛋白及 β2 微球蛋白亦明显高于正常对照组 (分别P <0 0 1,P <0 0 5 )。尿液α1 微球蛋白及β2 微球蛋白含量在≥ 6 0岁者中显著高于 <6 0岁者 (P <0 0 1)。　结论　血清α1 微球蛋白比 β2 微球蛋白能更早地反映肾小球滤过功能受损 ,敏感性更好。尿液α1 微球蛋白、β2 微球蛋白尤其是α1 微球蛋白比血清更敏感。更多还原

【Abstract】 Objective To assess the clinical significance of renal damage on the change of microglubin in urine and blood in elder patients with essential hypertension(EH). Methods There were seventy six patients with EH who were divided into two groups,the elder group(more than 60-year-old,n=45)and the younger group(less than 60-year-old,n=31) and 28 healthy persons as the control in the study.Their α 1-MG,β 2-MG in urine and blood were measured by radio-immunoassay. Results The serum level of α 1-MG in patients with EH was higher than in health control group(P<0.05,P<0.01).In the older group,serum level of β 2-MG in was significantly higher than that in the younger group(P<0.05);the uric level of α 1-MG,β 2-MG in patients with EH was much higher than that in controls group(P<0.01,P<0.05),and the uric level of α 1-MG,β 2-MG in the elder group was significantly higher than that in the younger group(P<0.05,P<0.01). Conclusion The change of the level of α 1-MG,β 2-MG in urine and serum could show the glomerular filtrating function was injued in elder patients with EH.更多还原