【摘要】 目的　探讨中枢神经系统 (CNS)感染患儿脑脊液 (CSF)中胰岛素样生长因子 Ⅱ (IGF Ⅱ )水平的变化及其与CSF中葡萄糖浓度、蛋白质浓度和白细胞计数的关系。方法　 45例CNS感染患儿分为 2组 ,其中细菌性脑膜炎 (BM) 2 4例、病毒性脑炎 (VE) 2 1例 ,取 15例无神经系统疾病患儿的CSF作为对照组。用免疫放射分析法 (IRMA)测定CSF中IGF Ⅱ的浓度。结果　 1.BM组CSF中IGF Ⅱ浓度 64 .5 6± 49.61ng/ml显著高于VE组 3 1.41± 7.16ng/ml(P <0 .0 1)和对照组 2 7.19± 6.85ng/ml(P <0 .0 1) ;2 .CSF中IGF Ⅱ浓度与CSF中葡萄糖浓度呈负相关 (r =- 0 .5 61　P <0 .0 1) ,与CSF中蛋白浓度呈正相关 (r =0 .83 9　P <0 .0 0 1)。结论　1.IGF Ⅱ参与CNS感染的病理生理过程 ;2 .IGF Ⅱ可能参与CNS感染时CSF中葡萄糖和蛋白浓度变化的调节 ;3 .测定CSF中IGF Ⅱ浓度可对BM和VE的鉴别诊断提供帮助。更多还原

【Abstract】 Objective To observe changes of insulin like growth factor Ⅱ (IGF Ⅱ) in cerebrospinal fluid (CSF) of children with infection of central nervous system (CNS) and the relations between the levels of IGF Ⅱ in CSF and the levels of glucose and protein and the white blood cell counts in CSF. Methods CSF samples were obtained from forty five patients:twenty four cases with bacterial meningitis(BM)and twenty one cases with viral encephalitis(VM). CSF control samples were obtained from fifteen children without any neurologic diseases. The levels of IGF Ⅱ were determined by immunoradiometricassay (IRMA). Results 1. The evels of IGF Ⅱ were markedly higher in the CSF of patients with BM 64.56±49.61 ng/ml than patients with VE 31.41±7.16 ng/ml ( P <0.01) and control group 27.19 ±6.85 ng/ml ( P <0.01). 2. The levels of CSF IGF Ⅱ of children with CNS infection negatively correlated with the levels of CSF glucose ( r =-0.561 P <0.01), but positively correlated with the concentrations of protein in CSF ( r =0.839 P < 0.001) .Conclusions 1. The change of IGF Ⅱ in CSF in children with CNS infection indicate that they may participate in pathophysiological mechanisms of CNS infection. 2. IGF Ⅱ may participate in the mechanism of changes of CSF glucose and protein levels in CSF in children with CNS infection. 3. Testing the levels of IGF Ⅱ may be valuable in diagnosis of BM and VE.更多还原