【摘要】 目的　探讨鼻咽癌放射治疗后颅神经损伤的临床特点、诊断、治疗及预后因素。方法　对 1990年 4月至 2 0 0 3年 2月收治的 86例鼻咽癌放射治疗后颅神经损伤患者的临床资料进行回顾性分析。结果　首程放疗患者颅神经损伤的潜伏期为 0 .5～2 1.0年 ,中位潜伏期为 4.5年。以舌下神经损伤最为多见 ( 68.6% )。 63例早期使用激素、抗生素、大量维生素等药物治疗的患者中 ,18例症状轻微改善 ,3 3例无明显变化 ,12例病情进展。随访 77例 ,死亡 2 8例 ,49例生存 ,出现神经症状者生存期 0 .6～ 13 .0年 ,3 2例生活不便 ,17例生活困难。结论　放射性颅神经损伤缺乏有效的治疗手段 ,它的发生与照射剂量、照射技术及分次剂量等因素有关 ,放射性颅神经损伤严重影响患者生存质量 ,应尽量减少其发生更多还原

【Abstract】 Objective To study the clinical features,diagnosis,treatment and prognostic factors of patients with radiation induced cranial neurophathy in nasopharyngeal carcinocma. Methods Eighty-six patients of radiation induced cranial neurophathy presented in our hospital during a period from April 1990 to February 2003 were analyzed retrospectively.Results The latency of the first course radiotherapy Patients ranged from 0.5～21.0 years,with a median of 4.5 years.Hypoglossal nerve injury was the most common injury(68.6%).sixty-three patients were teated with dexamethason,antibiotic and vitamin et al,with symtoms lightly relieved in 18 patients,but unimproved in 33 patients and being worse in 12 patients.Seventy-seven patients were followed up.28 patients died and 49 patients survived for 0.6～13.0 years.Conclusion Radiation injury of cranial nerve has no effective treatment methods.The incidence of radiation induced cranial neurophathy is associated with irradiation dose,radiotherapy technique and fractional dose.It is suggested that incidence of cranial nerves injury be decreased to improve the patien’s quality of life.更多还原