【摘要】 目的　探讨基质金属蛋白酶 (MMP 2 )在膀胱癌和阴茎癌组织中的表达及其意义。方法　采用免疫组化方法 ,检测42例膀胱癌和 45例阴茎癌组织中MMP 2的表达水平。结果　MMP 2在阴茎癌组织中的阳性表达率为 5 7.78% ( 2 6/4 5 ) ,高分化者阳性表达率为 45 .16% ( 14 /3 1) ,中低分化者阳性表达率为 85 .71% ( 12 /14 ) ,2组有显著性差异 (P <0 .0 5 )。MMP 2在膀胱癌组织中阳性表达率为 2 8.5 7% ( 12 /4 2 ) ,在移行细胞癌和腺癌组织中阳性表达率分别为 2 3 .68% ( 9/3 8)和 75 .0 0 % ( 3 /4 ) ,两者比较有非常显著性差异 (P <0 .0 1)。结论　MMP 2水平可作为阴茎癌和膀胱癌术后综合治疗及预后判断的生物学指标更多还原

【Abstract】 Objective To study the expression of matrix metalloproteinase-2 and its significance in bladder carcinoma and penis carcinoma.Methods The expression of MMP-2 was detected by SP Immunohistochemical technigue in 42 cases bladder carcinoma and 45 cases penis cancer.Results The expression rate of MMP-2 was 57.78%(26/45) in penis carcinoma.For penis carcinoma,the positive rate of MMP-2 was 45.16%(14/16) in high differentiation group and 85.71%(12/14) in low differentiation group (P<0.05).The positive rate of MMP-2 was 28.57%(12/42) in bladder carcinoma.For bladder carcinoma,the positive rate of MMP-2 was 75.00%(3/4) in adenocarcinoma and 23.68%(9/38) in transitional epithelium carcinoma(P<0.01). Conclusion The expression of MMP-2 can be taken as biological index of comprehensive treatment and prognosis in penis cancer and bladder cancer.更多还原