【摘要】 目的　探讨p5 3蛋白及nm 2 3 -H 1蛋白表达与肺癌临床病理特征的关系。方法　应用免疫组织化学S -P法检测118例肺癌组织中 p5 3及nm 2 3 -H 1蛋白的表达情况。 结果　p5 3、nm 2 3 -H 1蛋白表达与患者年龄、性别、淋巴结转移、浸润范围无关 (χ2 =0 .0 0 3 6～ 3 .5 761,P >0 .0 5 ) ,而与肿瘤组织学类型、分化程度及 5年生存率有关 (χ2 =9.5 45 2 ,P <0 .0 5 )。结论　p5 3、nm 2 3 -H 1蛋白表达可作为评估肺癌组织学类型、分化程度及 5年生存率的生物学指标更多还原

【Abstract】 Objective To determine the expressions of p53 and nm23-H1 protein in lung carcinoma and its relationship to the clinicopathology characteristics.Methods 118 cases of lung carcinoma tissues were stained by immunohistochemical SP.The positive rates in various differentiation and histologic types were compared statistically.Results The expression of p53?nm23-H1 protein were not related to age,lymph nodes metastases and invasion of the tumors(χ 2=0.0036～3.5761,P>0.05),but were related to histolopic types and differentiation of the tumors(χ 2=9.5452,P<0.05).Conclusion The results suggest that p53 and nm23-H1 might be an important biological marker in differentiation,histologic types and 5-year survival rate of lung carcinoma.更多还原