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单克隆抗体血型定型试剂转瓶培养生产工艺
Process technics of monoclonal antibodies blood type grouping reagents with roller bottle
【摘要】 研制成功单克隆抗体ABO血型定型试剂转瓶培养生产工艺 ,生产周期从静置培养生产的 5~ 6天缩短到 2~ 3天 ,产品所有质量指标均达到或超过国家标准 ,特别是抗体效价明显提高。实验及生产结果显示 ,该法简单易行 ,经济快速 ,投入低 ,产出高 ,生产时间短 ,产品质量高
【Abstract】 A new technics for producing monoclonal antibodies blood type grouping reagents was established.With 4 liters roller bottle,the quality indexes concerned with the products were reached or surpassed the state requirements for biologics,especially the antibodies titers were improved.The output of the antibodies was increased greatly and the production cycle was reduced from 5~6 days to 2~3 days.
【关键词】 单克隆抗体;
血型定型试剂;
转瓶培养;
生产工艺;
【Key words】 monoclonal antibodies; blood type grouping reagents; roller bottle;
【Key words】 monoclonal antibodies; blood type grouping reagents; roller bottle;
【基金】 国家火炬计划资助项目,项目编号 97D2 31B360 0 2 91
- 【文献出处】 生物学杂志 ,Journal of Biology , 编辑部邮箱 ,2003年04期
- 【分类号】TQ464
- 【被引频次】4
- 【下载频次】174