【摘要】 早期胚胎发育过程中 ,组织者能够诱导胚胎组织形成完整的体轴。研究表明细胞之间的信息交流是脊椎动物胚胎诱导作用的基础。Nodal作为早期胚胎诱导信号的关键成分 ,参与了中胚层和内胚层的形成、前 -后体轴的位置确定和左 -右体轴特化等一系列关键事件 ,表明Nodal信号在脊椎动物早期发育过程中具有重要作用。更多还原

【Abstract】 The concept of an embryonic organizer was first introduced from studies on amphibian development.This organizer was able to recruit host tissues to form a complete axis,including a head with appropriate D-V,A-P,and L-R patterning.Communication between cells during early embryogenesis establishes the basic organization of the vertebrate body plan.Nodal,a transforming growth factor β-related signal,is responsible for many of the events that configure the vertebrate embryo.The activity of Nodal signals is regulated extracellularly by EGF-CFC cofactors and antagonists of the Lefty and Cerberus families of proteins,allowing precise control of mesoderm and endoderm formation,the positioning of the anterior-posterior axis and left-right axis specification.;更多还原