【摘要】 目的:研究罗汉果粉及其提取物的降糖效果。 方法:用正常小鼠和糖尿病模型小鼠研究罗汉果粉及其提取物调节血糖的作用。罗汉果粉及其提取物以0.5、1.0、3.0g/kg·bw剂量连续30d给予正常小鼠和糖尿病模型小鼠,30d后眼眶取血,测定其空腹血糖并进行糖耐量实验。结果:罗汉果粉及其提取物对正常小鼠体重,血糖及糖耐量无影响;高剂量罗汉果粉(3.0g/kg·bw)及低、中剂量罗汉果提取物(0.5～1.0g/kg·bw)具有降低糖尿病模型小鼠空腹及餐后血糖的作用,且罗汉果粉的降血糖效果随其剂量增加而增强,高剂量组降血糖效果较好,而罗汉果提取物的降血糖效果随其剂量增加而降低,低剂量组降血糖效果最好。结论:罗汉果粉及其提取物对四氧嘧啶糖尿病小鼠的高血糖有防治作用。更多还原

【Abstract】 Objective: To study the efficacy of Siraitia grosvenori powder and its extracts on blood glucose in normal and diabeticmice. Methods: Normal mice and alloxan-induced diabetic mice were fed Siraitia grosvenori powder and its extracts at dosage of0.5、1.0、3.0g/kg·bw respectively for 30d. The blood glucose levels and oral glucose tolerance test (OGTT) of diabetic miceand normal mice were assayed. Results: Siraitia grosvenori powder and its extracts had no effect on the weight, blood glucoseand oral glucose tolerance of normal mice. Siraitia grosvenori powder at dose of 3.0g/kg·bw and Siraitia grosvenori extractsat dose of 0.5～1.0g/kg·bw could significantly lower the fasting blood glucose and blood glucose of 30min in oral glucose tolerancetest (OGTT) in diabetic mice. Farthermore the hypoglycemic effect decreased with the increase of dose of Siraitia grosvenoriextracts, but the increase of dose of Siraitia grosvenori powder showed better blood glucose-lowering effect increased. Conclusion:Siraitia grosvenori powder and its extracts had anti-diabetic preventive activity.更多还原