【摘要】 ①目的　了解Kail蛋白在胰腺癌组织中的表达及其意义。②方法　应用免疫组织化学方法 ,检测 12例正常胰腺和 4 7例胰腺癌组织中Kail蛋白的表达。③结果　正常胰腺组织中Kail蛋白阳性表达率为 83.3% ,明显高于胰腺癌组织中Kail蛋白阳性表达率 (χ2 =4 .0 8,P <0 .0 5 )。Kail蛋白阳性表达率与胰腺癌淋巴结和肝转移密切相关 (χ2 =5 .4 7、4 .83,P <0 .0 5 ) ,而与胰腺癌的侵袭能力、组织学分级和病人 1年生存率无关 (χ2 =3.14～ 3.5 8,P >0 .0 5 )。④结论　Kail蛋白异常表达在胰腺癌的转移中起重要作用更多还原

【Abstract】 Objective To investigate the expression of Kai1 protein in pancreatic cancer and evaluate its clinical significance. Methods Immunohistochemistry staining was used to detect Kai1 protein expression in the tissues of 47 pancreatic carcinomas and 12 normal pancreases. Results The rate of Kai1 protein expression in normal pancreases and pancreatic carcinomas was 83.3% and 51.1%, respectively (χ 2=4.08,P<0.05). The positive expression Kai1 protein was related significantly with lymph node and liver metastases (χ 2=5.47,4.83,P<0.05), but not with the invasion, differentiation and one-year survival rate of the patients (χ 2=3.14-3.58,P>0.05). Conclusion The abnormal expression of Kai1 protein may play an important role in the metastasis of pancreatic cancers.更多还原