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不同时期抽出聚丙烯酰胺水凝胶丙烯酰胺单体含量的检测

Measuring results of acrylamid monomer drew polyacrylamid hydrogel at the different time

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【作者】 鲁开化谢俊杰刘会省曹孟君金宝玉雷永红高景恒

【Author】 LU Kai-hua, XIE Jun-jie, LIU Hui-xing, et al. (Department of Plastic Surgery, Xijing Hospital, the Fourth Military Medical University, Xi′an 710032, China)

【机构】 第四军医大学西京医院整形外科中心西安近代化学研究所西安铁一局医院深圳富华美容医院咸阳彩虹医院辽宁省人民医院 陕西西安710032陕西西安710032

【摘要】 目的 探讨聚丙烯酰胺水凝胶注入动物及人体后 ,在体内环境作用下 ,经过一段时间 ,是否有丙烯酰胺单体释放出来。方法 在不同时期从注射处抽出或取出标本 ,进行高压液相色谱仪外标法检测。结果 小香猪 :半年以上标本 1份 ,1年以上标本 3份。兔 :6~ 8个月标本 6份。人体乳房内抽出标本 :2 2例人 2 6份。检测结果均 <3.6×10 6,未高出注射前标准样品检测的数值。结论 初步提供在近期内未发现丙烯酰胺单体析出的结果

【Abstract】 Objective To explore possibility of degradation of polyacrylamid hydrogel and release of acrylamid monomer after it was injected into body for a period of time. Methods High performance liquid chromatography was employed to detect acrylamid monomer in the sample that was drew from injected area after which was injected for a period of time. Results Mini-musk swine: 1 sample was over six months, and 3 were over a year. Rabbit: 6 samples were 6 to 8 months. Human being breasts: 26 samples from 22 people. The resultc show that the amount of acrylamid monomer is lower than 3.6×10 6 which were not higher than the value before injection. Conclusion Primary finding proves that no acrylamid monomer releases out after the polyacrylamid hydrogel (PAG) injected into the body.

  • 【文献出处】 实用美容整形外科杂志 ,Journal of Practical Aesthetic and Plastic Surgery , 编辑部邮箱 ,2003年06期
  • 【分类号】R655.8
  • 【被引频次】14
  • 【下载频次】113
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