【摘要】 目的　深入研究中枢神经系统海绵状血管瘤 (CH)临床表现与病理特点之间的内在联系 ,为临床治疗该疾病提供必要的理论依据。方法　将临床随机选取的CH标本 70例分为出血 未出血、脑内 脑外、单发 多发组、分别进行常规HE染色以及α 平滑肌抗体 (α SMA)、血管内皮细胞生长因子 (VEGF)、VEGF酪氨酸激酶受体 (Flt 1)免疫组化染色 ,根据染色强度进行分类对照研究。结果　出血组VEGF、Flt 1染色强度明显高于未出血组 ,α SMA表达弱于未出血组 ;脑外组表现为弹性较好的厚壁血管 ,脑内组为弹性较差的薄壁血管 ;多发CH系生物学行为相对活跃的病灶。结论　中枢神经系统CH临床表现与其病理特点密切相关。更多还原

【Abstract】 Objective To explore the relation between the clinical presentation and pathological characteristic of central nervous cavernous hemangiomas.Methods Seventy surgical samples of cavernous hemangiomas were divided into bleeding and non bleeding groups, intra and extra cerebral groups, single and multiple lesions groups.All these samples were respectively stained with routine HE and immunohistochemically stained with α SMA?VEGF and Flt 1. A comparison analysis was made according to the expression intensity. Results The bleeding group expressed more VEGF, Flt 1 and less α SMA obviously than non bleeding one. The extracerebral group, completely different from the intracerebral one, presented elastic and thick wall vessels. The multiple cavernous hemangiomas were biologically active lesions.Conclusion The clinical presentation of central nervous cavernous hemangiomas was based on its pathology.更多还原