【摘要】 核受体的研究近几年已有飞速的发展。LXRa(Liver X Receptor a)是一种与脂类代谢有关的核受体。研究发现LXRa的靶基因具有调节脂类的吸收、运输、转化和生物合成的功能,此外,LXRa在糖类的代谢等方面也有重要的调控作用。研究结果表明LXRa与动脉粥样硬化的发生有非常密切的关系。目前利用LXRa为靶标进行抗动脉粥样硬化药物筛选已经成为一个重要的研究方法。更多还原

【Abstract】 In recent years, the research in nuclear receptors has been developed rapidly. LXRa, which belongs to a subgroup of nuclear receptors , is considered to play an important role in the regulation of lipid metabolism. It has been found that LXRa target genes have the ability in regulating the assimilation , transportation , transformation , and biosynthesis of lipids. In addition , LXRa also takes part in the regulation of glucose metabolism . To date, it has been confirmed that the exploration of anti-atherogenic pharmacological agents using LXRa as target is a promising research project.更多还原