【摘要】 目的　探讨急性CO中毒后迟发性脑病 (DEACMP)患者脑脊液 (CSF)髓鞘碱性蛋白 (MBP)和天门冬氨酸氨基转移酶 (AST)、乳酸脱氢酶 (LDH)、神经元特异性烯醇化酶 (NSE)水平的变化及临床意义。方法　对4 9例DEACMP患者均在急性期入院 3d内抽取CSF标本进行MBP、AST、LDH、NSE测定 ,并与对照组比较 ;对其中 34例于治疗 30d后再次采取标本复查 ,对比分析治疗前后上述指标的变化。结果　患者组急性期CSFMBP、LDH、NSE水平均明显高于对照组 (P <0 .0 5～ 0 .0 1) ,阳性率分别为 82 %、18%和 5 1% ;治疗后明显下降 ,与治疗前比较差异有显著性 (P <0 .0 5～ 0 .0 1)。患者组与对照组及患者组治疗前后CSFAST差异无显著性 (P>0 .0 5 )。结论　CSFMBP和NSE水平可作为DEACMP诊断和病情判断的生化指标更多还原

【Abstract】 Objective To study clinical significance of the level changes of myelin basic protein(MBP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and neuron\|specific eonlase(NSE) in cerebrospinal fluid in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods The levels of MBP, AST, LDH and NSE of cerebrospinal fluid in 49 patients with DEACMP within 3 days after attack were measured. The levels were measured again after 30 day’s treatment in 34 patients. Results The levels of CSF MBP,LDH and NSE were significantly higher in patients than in controls( P <0.05～0.01), the positive rates were 82%, 18% and 51% respectively. The levels of CSF MBP, LDH and NSE were obviously lower after treatment than before treatment( P < 0.05 ～0.01). CSF AST activities had no significant difference between the patients and controls( P > 0.05 ). Conclusions CSF MBP and NSE could be useful as biochemical diagnostic indicators for DEACMP.更多还原