【摘要】 目的　探讨国产尿激酶与重组链激酶溶栓治疗下肢非急性期深静脉血栓形成的早期疗效。方法　非急性期深静脉血栓形成患者 43例 ,分为 2组。尿激酶组 ( 2 2例 )予国产尿激酶 5 0万U ,重组链激酶组 ( 2 1例 )予链激酶 5 0万U。两药均溶于 5 0 0ml 5 %葡萄糖注射液中 ,每日 1次静脉滴注 ,连用 5d。两组常规治疗相同。结果　两组症状缓解率中 ,重组链激酶组下肢周径缩小的程度和血管部分再通率明显优于尿激酶组 (P <0 .0 5 )。结论　重组链激酶治疗下肢非急性期深静脉血栓形成的早期疗效优于国产尿激酶 ,但药物不良反应较多。更多还原

【Abstract】 Objective To appraise the earlier effect of urokinase and recombinant streptokinase in treatment of non acute deep vein thrombosis. Methods 43 cases with non acute deep vein thrombosis were divided into two groups. 22 cases were treated with 500 000 U urokinase, 21 with 500 000 U recombinant streptokinase. The two drug were dissolved in 5% glucose solution 500 ml each and were infused 5 times (once daily). Results The two groups showed great difference in remission rate of symptoms and decreased size of circumference of lower limb. Difference of partial recanalization was significant.Conclusions The early efficacy of recombinant streptokinase was superior to that of urokinase, but its side effect is also more frequent than the latter.更多还原