【摘要】 目的　探讨钙粘附素在宫颈上皮内瘤变 (CIN)及浸润性鳞癌中的表达。方法　采用免疫组织化学方法对正常宫颈鳞状上皮、不同级别宫颈CIN及宫颈浸润性鳞癌各 10例进行上皮型钙粘附素 (E cadherin)染色。结果　E cadherin在正常宫颈上皮的表达分布均在鳞状上皮基底层细胞和细胞连接处的膜缘 ,而在CIN的表达分布与CIN的级别有关 ,宫颈浸润性鳞癌E cadherin表达明显减少。结论　根据E cadherin的表达分布可帮助判断CIN的级别更多还原

【Abstract】 Objective To study the clinical significance of E cadherine expression in cervical epithelial neoplasia (CIN) and cervical squamous carcinoma. Methods E cadherine expression by immunohistochemical staining formalin fixed, paraffin embedded specimens for each 10 cases of normal cervix, CIN Ⅰ, CIN Ⅱ, CIN Ⅲ and squamous cancer respectively. Results E cadherine was expressed in all normal cervical epithelia in the basal cell layers of intercellular junction. E cadherine expression distribution was correlated to the pathologic grade of CIN. In squamous carcinoma, negative E cadherine expression was showen significantly more frequent. Conclusion E cadherine expression is one of the useful parameters for evaluating the grade of CIN.更多还原