【摘要】 目的　为探讨HLA Ⅱ类基因与类天疱疮 (BP)的相关性 ,了解BP的免疫遗传发病背景。方法　采用PCR SSOP方法对上海地区汉族 5 6例BP患者和 15 0例健康对照者进行了HLA DRB1、DQA1、DQB1位点等位基因分型。结果　发现HLA DRB1 10 0 1与DQB1 0 5 0 1紧密连锁 ,其基因频率BP组与对照组比较明显增高 ;DRB1 0 4与DQB1 0 3 0 2紧密连锁 ,其基因频率与对照组比较也明显增高 ;DRB1 12基因频率BP组与对照组比较明显降低 (P =0 .0 0 7,RR =0 .3 5 8)。结论　DRB1 10 0 1、DRB1 0 4可能为上海地区BP患者的易感基因 ,而DRB1 12 ( 12 0 1, 12 0 2 )可能为上海地区汉族BP患者的保护基因更多还原

【Abstract】 Purpose To investigate the association between Bullous pemphigus(BP) and HLA class Ⅱ genes. Methods Fifty six cases of BP patients and 150 normal individuals in Shanghai area were genotyped for DRB1,DQA1,DQB1 locus by PCR?SSOP method. Results HLA?DRB1*10(*1001) linked with DQB1*0501,DRB1*04 linked with DQB1*0302, frequencies of these two alleles were significantly increased in BP group compared with normal control; DRB1*12(*1201,*1202) decreased in BP group compared with normal control. Conclusions It is suggested that HLA?DRB1*1001,DRB1*04 may be the susceptible gene and DRB1*1201,*1202 may be the protective genes of BP patients in Shanghai area.更多还原