【摘要】 研究不同剂量甲基纤维素(MethylcelluloseM450)对卵巢摘除中老年雌性大鼠体重的调节作用。对6月龄雌性大鼠施卵巢切除术后4个月起胃饲高中低三种剂量甲基纤维素30d,观察其体重、腹腔脂肪重量、脂肪细胞数量、大小、血脂、血胆固醇水平的变化。结果显示,给予甲基纤维素100mg/kg(中剂量)和200mg/kg(高剂量)组,大鼠体重、腹腔脂肪重量及脂肪细胞大小均明显低于对照组(P<0.05);高剂量纤维素组血甘油三酯,总胆固醇含量明显下降(P<0.05)。结果提示,中、高剂量(即>100mg/kg)甲基纤维素组对卵巢摘除的中老年大鼠有明显减肥作用,并有一定降血脂作用。30mg/kg(低剂量)纤维素组则无作用(P>0.05)。更多还原

【Abstract】 To investigate the weightreducing effect of methyl cellulose M450 on aged ovariectomized (OVX) rats, the cellulose was administered intragastrically to tenmonth old rats that were ovariectomized in sixmonth for 30 days, the body weight, weight of celiac fat tissue, adipocyte number,adipocyte size, blood lipid and cholesterol were observed. The results showed that the body weight, weight of celiac fat tissue, adipocyte size in the rats of 100 mg/kg and 200 mg/kg cellulose groups were significantly lower than those in control group (P<0.05); and the level of blood lipid and cholesterol were lower too in the 200 mg/kg group (P<0.05);the results suggested that administration of cellulose (>100 mg/kg) to rats for 30 days have evident weightreducing effect and can also decrease the blood lipid level, but 30 mg/kg cellulose group have no effect at all (P>0.05).更多还原