【摘要】 目前已经克隆了 3种甘丙肽受体 (GalR1,GalR2 ,GalR3) ,它们都是与G蛋白相偶联的受体 . 3种甘丙肽受体的氨基酸序列、药理学特性以及第二信使系统各不相同 .GalR1/ 3受体可以抑制腺苷酸环化酶并可以激活钾通道 ,GalR2受体可以激活磷脂酶C并增加胞内钙离子浓度 .用RNA印迹、反转录PCR以及原位杂交等技术对上述 3种甘丙肽受体在人、大鼠和小鼠中的分布进行了研究 ,发现它们具有不同的分布特征 ,提示不同的甘丙肽受体可能参与不同的生理过程更多还原

【Abstract】 Three types of galanin receptor (GalR1, GalR2, GalR3) have been cloned to date, and identified to be G protein coupled receptors. These three galanin receptors show differences in their amino acids sequences, pharmacological properties, as well as in the second messenger system. Activation of GalR1/3 induces inhibition on adenylyl cyclase and to activate K + channels, while activation of GalR2 leads to the stimulation of phospholipase C and intracellular Ca 2+ mobilization. The distribution of the three galanin receptors in human, rats and mice have been investigated by Northern blot, RT PCR and in situ hybridization. The different distribution of the galanin receptor indicates that galanin participates a broad range of physiological activities.更多还原