【摘要】 实验证明细胞色素c具有很强的抗氧化功能 ,在线粒体中氧化态的细胞色素c直接清除O2 ·,还原态的细胞色素c清除H2 O2 .由于呼吸链传递电子合成ATP的同时 ,总有少部分电子从呼吸链底物端的复合物Ⅰ和Ⅲ漏出 ,而且漏出的电子首先使氧分子还原成O2 ·,然后O2 ·歧化成H2 O2 ,所以细胞色素c清除O2 ·和H2 O2 的功能使呼吸链出现了两条电子漏旁路 .细胞色素c通过这两条电子漏路径实现其控制线粒体中O2 ·和H2 O2 水平的功能 .根据两条电子漏旁路都是O2 ·代谢路径的事实 ,引进了线粒体自由基代谢的概念 ,并从自由基代谢失调的角度探讨了呼吸链电子漏在细胞凋亡中的作用更多还原

【Abstract】 Cytochrome c has been proved to be a powerful scavenger of O 2 · and H 2O 2, the ferricytochrome c scavenges O 2 · and the ferrocytochrome c scavenges H 2O 2. As the respiratory chain leak some electrons from complex Ⅰ and Ⅲ to generate O 2 · and then O 2 · dismutate to H 2O 2,the scavenge of O 2 · and H 2O 2 by cytochrome c makes respiratory chain operated with two electron leak bypass. Cytochrome c plays a role to keep O 2 · and H 2O 2 in the normal physiological level in mitochondria. A concept of radical metabolism is introduced into mitochondria based on the electron leak bypass is the metabolic path of O 2 ·. The role of electron leak of respiratory chain in cell apoptosis is discussed in the dysfunction of radical metabolism of mitochondria.更多还原