【摘要】 促性腺激素释放激素 (GnRH)是下丘脑分泌的十肽激素 ,是神经、免疫、内分泌三大调节系统互相联系的重要信号分子 ,对生殖调控具有重要意义 .GnRH类似物是近年来应用最广的多肽类激素新药之一 .就GnRH及其受体的结构及分布、GnRH在垂体和性腺水平调控生殖的一系列证据、影响GnRH释放的因素等进行了综述 ,并展望了GnRH研究的发展趋势及应用前景 .更多还原

【Abstract】 The decapeptide gonadotropin- releasing hormone(GnRH)is a kind of regulative neuropeptide synthesized by GnRH- producing cell bodies in hypothalamus and is an important information molecule among nervous, immune and neuroendocrine systems. GnRH plays a pivotal role in the regulation of reproduction. In recent years, GnRH- analogues have been one of the most widely applied hormonal medicine. The research progresses of GnRH were reviewed, including structure, localization and distribution of GnRH and its receptor. A series of evidences on GnRH regulating reproduction activity at different levels such as pituitary and gonad, factors affecting secretion of GnRH, as well as prospects of studies on GnRH are also introduced.更多还原