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新生儿肺透明膜病的临床病理诊断分析

Analysis on the Clinical and Pathological Diagnosis of Neonatal Hyaline Membrane Disease

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【作者】 杨庆南朱建幸张忠德

【Author】 YANG Qing-nan, ZHU Jian-xing, ZHANG Zhong-de( Department of Pediatrics, Shanghai Children ’ s Medical Center, Xinhua Hospital, SSMU, Shanghai 200092, China)

【机构】 上海第二医科大学新华医院儿内科上海儿童医学中心上海第二医科大学新华医院病理科 上海 200092上海 200092

【摘要】 目的 提高新生儿肺透明膜病临床诊断的准确性。方法 回顾分析经尸检病理确诊的42例新生儿肺透明膜病的临床资料。结果 病理诊断和临床诊断相一致的30例(71.4%),不相一致的12例(28.6%);X线胸片检查,前者均为阳性,后者则全为阴性(P<0.01)。病理检查提示全部肺透明膜形成36例(85.7%),部分性肺透明膜形成6例(14.3%);前者胸片阳性29例,后者仅1例阳性(P<0.01)。结论 新生儿肺透明膜病临床表现多样,及时拍摄胸片对确诊和治疗新生儿肺透明膜病有重要意义。

【Abstract】 Objective To highlight the understanding of neonatal hyaline membrane disease (HMD) and improve the veracity of clinical diagnosis of HMD. Methods Retrospective analysis of pathological results and clinical data from 42 patients with HMD was performed. Results Concordance of the pathological diagnosis and clinical diagnosis of HMD was found in 30 cases (71.4% ) while clinical diagnosis of 12 cases was not concurred with the pathological data (28.6% ). The pathology provided complete patterns of hyaline membrane in the entire lungs in 36 cases (85. 7% ) while 6 showed partial hyaline membrane patterns in the various region of the lungs (14. 3% ). There was significant difference between pathology and clinical diagnosis according to the appearance of chest X - ray ( P < 0. 01 ) . With great difference in chest X - ray between complete and partial formation of hyaline membrane pathologically ( P < 0. 01 ) . Conclusion As the clinical presentation in neonates with HMD varied greatly, its pivotal to have chest X -ray films taken timely to be conductive to the diagnosis and treatment of neonates with HMD.

  • 【文献出处】 上海第二医科大学学报 ,Acta Universitatis Medicinalis Secondae Shanghai , 编辑部邮箱 ,2003年S1期
  • 【分类号】R722.12
  • 【被引频次】5
  • 【下载频次】122
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