【摘要】 目的比较西替利嗪与酮替芬治疗学龄期儿童急性荨麻疹的疗效和不良反应。　方法 6 ～12岁急性荨麻疹病人 98例 ,分别给予口服西替利嗪 (4 9例 ,10mg ,1次 /d)及酮替芬 (4 9例 ,2 /3片 ,2次 /d) ,均用药 7d ;根据治疗前后病损总积分下降指数 ,分析疗效并观察比较不良反应。　结果治疗总有效率 ,西替利嗪组为 95 .8% ,酮替芬组为85 .7% ,二组无显著差异 ;西替利嗪组仅有 2例出现注意力或记忆力减退 ,酮替芬组则出现嗜睡 10例 ,口干 5例 ,注意力或记忆力减退 2例。　结论西替利嗪对学龄期儿童急性荨麻疹的疗效并不明显优于酮替芬 ,但其不良反应轻微更多还原

【Abstract】 Objective To compare the efficacys and adverse reaction between cetirizine and ketotifen fumarate in the treatment of acute urticaria for school children. Methods Ninty-eight school children patients (age,6～12 years) with acute urticaria were divided into two groups: 49 patients received oral cetirizine once 10mg daily and the others 2/3 tablet oral ketotifen fumarate twice daily for 7d. The total integral falling-exponents of disease damage were analysed and compared with adverse reaction and result prior and after treatment. Results The effective rate of the cetirizine group was 95.8% and the ketotifen fumarate group was 85.7%. There was no obvious difference in both groups. The cetirizine group had 2 cases of decrease in memory or attention merely. The ketotifen fumarate group had 10 cases of somnolence, 5 cases of mouth drying and 2 cases of deterioration of memory or attention. Conclusion The efficacy of cetirizine treatment acute urticaria for school children is not obviously better than ketotifen fumarate, but its adverse reaction is much slighter.更多还原