【摘要】 为探讨肝素对乙型肝炎肝纤维化的影响 ,将 75例慢性乙型肝炎患者随机分为 A、B、C组 ,分别给予常规治疗、肝素 /低分子量肝素和 α-干扰素治疗。治疗前后分别检测血丙氨酸氨基转移酶 (AL T)、凝血酶原时间(PT)、总胆红素 (TBIL)、透明质酸 (HA)和 型胶原 ( - C)水平。 A组和 C组分别有 3例于治疗前后行肝活检术 ,B组中 7例分别于治疗前后行肝活检术。结果治疗后 A、B组 AL T、TBIL水平较治疗前显著下降 (P<0 .0 5 ) ,C组 AL T较治疗前略有升高 ;B组治疗后 HA、 - C水平显著下降 (P<0 .0 5 ) ,而 A、C两组 HA、 - C反较治疗前有所升高 (P>0 .0 5 ) ;A、C两组治疗前后肝纤维化程度无明显变化 ,B组治疗前肝组织胶原纤维增生显著 ,治疗后明显减轻。结论 :肝素可抑制乙型肝炎肝组织中胶原纤维增生 ,α-干扰素短期应用无明显的抗肝纤维化作用更多还原

【Abstract】 This study was aimed to evaluate the effects of heparin and α-IFN on liver fibrosis in patients with chronic hepatitis B.Seventy-five cases were divided into group A,B and C.The three groups were given regular treatment,heparin/low molecular weight heparin(LMWH) treatment and α-IFN treatent,respectively.Hepatic functions,serum hyaluronic acid(HA) and IV-type collagen levels were measured before and after the treatment.Three cases were taken liver biopsy before and after treatment respectively in group A and C,seven cases were taken liver biopsy twice in group B.The resalts showed that after treatment,hepatic functions became significantly better in group A and B,but ALT level in group C elevated slightly.Serum HA and IV-type collagen levels in group B decreased significantly after treatment,unlike those in heparin group A and C.Collagen proliferation lessened in group B after treatment.It’s concluded that heparin/LMWH can inhibit collagen proliferation in liver tissues with hepatitis B,the antifibrotic effects of short term usage of α-IFN is not remarkable.更多还原