【摘要】 对 36例临床 ～ 期非小细胞肺癌患者行立体定向放射治疗 ,病灶 <3cm者采用弧形照射 ,剂量 10～15 Gy/次 ,共 3～ 5次 ;>3cm者采用非共面适形野 ,剂量 5～ 8Gy/次 ,共 6～ 12次。结果 :近期完全缓解 ( CR)率为 5 3% ,部分缓解 ( PR)率为 36 % ,总有效率 ( CR+ PR)为 89%。肿瘤直径 <3cm者 CR率为 76 .5 % ,>3cm者为 31.5 % ,差异有显著意义 ( P <0 .0 5 ) ;其 1、 2年生存率分别为 83.3%、 5 2 .4 % ; 期、 期 1年生存率分别为 96 %、 5 4 .5 % ,差异有显著意义 ( P <0 .0 1)。放射性肺反应早期多为 0级 ,晚期肺反应多为 1级。说明立体定向放射治疗技术治疗早期非小细胞肺癌是安全、有效的 ,近期疗效满意 ,远期疗效有待进一步观察更多还原

【Abstract】 36 patients with stage Ⅰ～Ⅱ non small cell lung cancer were treated with stereotactic radiotherapy Tumor<3cm had arc irradiation,with dose 10～15Gy/f,totally 3～5 fractions Tumor≥3cm had 3 dimensional conformal field,with dose 5～8 Gy/f,totally 6～12 fractions The short term treatment result showed the complete response(CR)rate was 53%,the partial response(PR)rate was 36%,the overall response(CR+PR)rate was 89% CR rate for tumor<3cm was 76 5%,and CR rate for tumor≥3cm was 31 5%,it has the significant difference(P<0 05) 1 and 2 year survival rates were 83 3% and 52 4% 1 year survival rates for stage Ⅰ and stage Ⅱ were 96% and 54 5% with the difference significant(P<0 01) Acute radiation pneumonitis were mostly Grade 0 Late radiation plumonary fibrosis were mostly Grade 1 This suggests stereotactic radiotherapy for early stage non small cell lung cancer is safe and effective The short term treatment result is significant The long term treatment result needs further followup更多还原