【摘要】 采用聚合酶链反应和限制性片段长度多态性 ( PCR- RFL P)技术 ,对 10 2例缺血性脑卒中患者和 90例健康人进行β-纤维蛋白原 - 45 5 G/ A(β- Fg- 45 5 G/ A)基因多态性分析 ,并测定其血浆纤维蛋白原 ( Fg)水平。结果表明 ,两组携带 A等位基因者 (基因型为 G/ A和 A/ A)血浆 Fg水平均较同组 G/ G基因型者明显增高 ( P<0 .0 0 1) ;A等位基因频率患者组明显高于对照组 ( P<0 .0 5 )。提示 β-纤维蛋白原 - 45 5 G/ A基因多态性与血浆 Fg水平升高有关 ,A等位基因可能是与缺血性脑卒中发病有关的遗传因素更多还原

【Abstract】 fibrinogen-455G/A gene polymorphism was analyzed by using PCR-RFLP in 102 patients with ischemic stroke and 90 healthy cases.Turbidimetric assays were used to measure plasma fibrinogen levels of all samples.Results showed that the plasma fibrinogen level in the samples of genotype A/A and G/A was higher than that in the samples of G/G in the same group(P<0.001).The frequence of A-allele was higher in the cases with ischemic stroke than that in the healthy cases(P<0.05).These suggest that the concentration of plasma fibrinogen is affected by the β-fibrinogen-455G/A gene polymorphism in the general and A-allele may be a susceptible predictor of ischemic stroke.更多还原