【摘要】 目的:应用多普勒组织成像技术(DTI)评价肥厚型心肌病患者(HCM)左心室局部与整体舒缩功能。方法:采用DTI技术测量HCM患者室间隔和左心室侧壁中段以及二尖瓣瓣环-室间隔和二尖瓣瓣环-侧壁交界处的收缩期、舒张早期和舒张晚期DTI速度峰值(Sm1～4、Em1～4、Am1～4),并与正常组进行比较。结果:HCM患者室间隔和侧壁中段以及二尖瓣瓣环-室间隔和二尖瓣瓣环-侧壁交界处收缩期Sm1～4与正常组相比无显著差异,但舒张早期Em1～4明显低于正常,舒张晚期Am1～4明显高于正常,Em1～4/Am1～4明显减低;在正常人中,Em1/Am1和Em2/Am2无显著性差异(P>0.05),但HCM患者Em1/Am1明显低于Em2/Am2(P<0.05),且该组患者室间隔厚度明显大于侧壁厚度(2.36±0.50)cmvs(1.20±0.23)cm,P<0.05。结论:DTI技术测量的室壁运动速度可早期而准确反映HCM患者左心室舒缩功能的变化,为左心室舒缩功能的评价提供了一种新的方法。更多还原

【Abstract】 Objective:To quantitatively analyze r eg ional and global left ventricular systolic and diastolic function in patients wi th hypertrophic cardiomyopathy(HCM)by Doppler tissue imaging(DTI).Meth ods :Seventeen patients with HCM and thirteen control subjects were studied using D TI.DTI data were acquired from medium segments of interventricular septum and lateral wall as well as septum and lateral mitral annulus from four-chamber vie ws.Results:Myocardial segments in patients with HCM had,in comparison with co ntrols,lower peak velocity of the early diastolic wave(Em),higher peak veloc ity of the late diastolic wave(Am)and decreased Em/Am ratio.But there was n o difference in peak velocity of systolic wave.Conclusion:Regional and global left ventricular diastolic function in HCM patients decreases.DTI has more use ful noninvasive modality for the early recognition of left ventricular function in patients with HCM.更多还原