【摘要】 目的　比较利培酮与氟派啶醇治疗难治性精神分裂症的疗效和副反应。方法　 84例符合入组条件的难治性精神分裂症患者 ,随机分为两组 ,分别应用利培酮和氟哌啶醇治疗 12周 ,应用阳性和阴性症状量表 (PANSS)和副反应量表 (TESS)评定疗效和副反应。结果　利培酮组总有效率为 6 4.2 9% ,明显高于氟哌啶醇组的 4 2 .85 %。两组间在PANSS总分、阴性症状量表分及一般病理症状量表分值方面的差异具有显著性 (P <0 .0 1)。结论　利培酮对难治性精神分裂症的疗效优于氟哌啶醇 ,对阴性症状的效果尤其明显更多还原

【Abstract】 Objective To compare the efficacy and side effects of risperidone and haloperidal on patients with treatment-resistant schizophrenia.Methods Eighty four patients with treatment-resistant schizophrenia were randomly assigned to risperidone or haloperidal treatment for 12 weeks.Efficacy and side effects were measured with PANSS and TESS.Results The overall efficacy rate of risperidone (64.29%) was higher than that of haloperidal (42.85%).There were statistical differences in total score,N and G Subscale scores of PANSS between the two groups (P<0.01).Conclusion Risperidone is superior to haloperidal in the treatment-resistant schizophrenia,especially to negative symptoms.更多还原