【摘要】 研究了芳香醇胺类药物对映体的分离方法 .用D 10 樟脑磺酸铵作为手性离子对试剂添加到流动相中 ,采用薄层色谱法 ,在普通的硅胶HF2 54薄层板上 ( 2 .5cm× 10cm) ,以不同配比的二氯甲烷———甲醇混合液为流动相 ,通过降低温度的方法 ( 0℃ ,冰箱内 ) ,分离了两种芳香醇胺类药物的对映体———舒喘灵和噻吗心安 .实验证明 ,两种药物的对映体得到了完全分离 ,且该方法简单易行、经济更多还原

【Abstract】 Two chiral aromatic alcohol amino drugs, Salbutamol and Timolol, were resolved by thinlayer chromatography (TLC) on the silica gel HF 254 plates(2.5?cm×10?cm), by using the ammonium D 10 campor sulfonate (CSA) as chiral ion pair interaction agent which was added to the mobile phase in the ammonium form. All developments were carried out at lower temperature (0?℃,in a refrigerator). Analytical reagent grade methanol and dichloromethane can be directly used as mobile phase without further drying. These separation conditions were easily obtained. This method is relatively inexpensive and attractive.更多还原