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美托洛尔对扩张型心肌病患者血浆TNF-α水平影响研究

Effects of Metoprolol on Circulating Levels of Tumor Necrosis Factor-Alpha in Patients with Congestive Heart Failure Secondary to Idiopathic Dilated Cardiomyopathy

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【作者】 刘媛余细勇林秋雄单志新杨敏钱忆之

【Author】 LIU Yuan, YU Xi yong, LIN Qiu xiong,SHAN Zhi xin, YANG Min, QIAN Yi zhi (Department of Cardiology,Guangdong Provincial Cardiovascular Institute,Guangzhou 510080,China)

【机构】 广东省心血管病研究所心内科广东省心血管病研究所心内科 广州510080广州510080广州510080

【摘要】 目的探讨美托洛尔治疗对扩张型心肌病心衰患者血浆肿瘤坏死因子-α(TNF-α)水平的影响及其TNF-α与心功能分级的关系。方法43例扩张型心肌病心衰患者,随机分为常规治疗组和美托洛尔治疗组,予以药物干预4w,放免法检测治疗前后患者血浆TNF-α水平,正常对照组30例,同时检测血浆TNF-α水平。结果扩张型心肌病心衰患者血浆TNF-α水平明显高于正常对照组(P<0.01),且在心衰组血浆TNF-α水平与临床心功能分级呈明显的正相关(P<0.01)。心衰患者经美托洛尔治疗后血浆TNF-α水平明显低于治疗前(P<0.05),而常规治疗组治疗前后血浆TNF-α水平无明显差异(P>0.05)。结论扩张型心肌病心衰患者血浆TNF-α升高,且与心衰严重程度密切相关,说明TNF-α参与了心力衰竭发生、发展的病理生理过程。美托洛尔能显著降低心衰患者TNF-α水平,可能是其治疗CHF有益作用的机制之一。

【Abstract】 Objective This study was designed to examine the levels of plasma tumour necrosis factor α( TNF α) in patients with congestive heart failure (CHF) secondary to idiopathic dilated cadiomyopathy. Moreover, the effects of metoprolol were also investigated. Methods The levels of TNF αwere measured in 43 cases with CHF and in 30 normal controls using ELISA test. 43 patients were divided into two groups. One group was treated with traditional drugs while the second group was treated only with metoprolol for 4 weeks. Results The levels of TNF αwere related to the cardiac function. And plasma TNF αdecreased in patients suffered from CHF after 4 weeks treatment with metoprolol. Conclusion The finding indicated that over production of TNF αmay be related to the pathogenesis of heart failure secondary to idiopathic dilated cardiomyopathy. Decreasing of plasma TNF αby metoprolol may contribute to the beneficial effects of metoprolol in patients with heart failure.

  • 【文献出处】 热带医学杂志 ,Journal of Tropical Medicine , 编辑部邮箱 ,2003年04期
  • 【分类号】R542.2
  • 【下载频次】38
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