【摘要】 MALT(黏膜相关性淋巴组织 )淋巴瘤的形成与幽门螺杆菌的感染密切相关 ,黏膜内幽门螺杆菌的克隆增殖导致淋巴细胞浸润进而形成获得性MALT。通过直接和间接免疫刺激 ,幽门螺杆菌的感染不仅引起并维持B细胞群的活跃增殖 ,还参与或促进异常基因的形成及反应性B细胞的恶变。MALT淋巴瘤的早期阶段 ,根除幽门螺杆菌疗法有效 ;后期阶段 ,由于肿瘤又获得了其他一些异常基因 ,其生长不依赖于幽门螺杆菌 ,因而根除幽门螺杆菌疗法无效。根除幽门螺杆菌后 ,70 %～ 80 %的早期低度恶性MALT淋巴瘤可以完全消退更多还原

【Abstract】 The development of mucosa associated lymphoid tissue(MALT) lymphoma is closely associated with Helicobacter pylori infection.Bacterial colonisation of the mucosa triggers lymphoid infiltration and the formation of acquired MALT.The bacterial infection induces and sustains an actively proliferating B-cell population through direct and indirect immunological stimulation.Moreover,the bacterial infection is involved in or promote the acquisition of genetic abnormalities and malignant transformation of reactive B-cells.At the early stages,the tumour can be treated by the eradication of the bacterium,whereas at later stages the tumour may escape its growth dependency through acquisition of additional genetic abnormalities and may not respond to the eradication of the bacterium.70%～80% of the early low-grade gastric MALT lymphoma may completely regress following eradication of the bacterium.更多还原