【摘要】 目的 :研究MOD方案对难治性、复发性多发性骨髓瘤 (MM)的疗效和毒性反应。方法 :随机将4 3例难治、复发性MM患者分为两组 ,MOD组 (治疗组 ) 2 2例 ,采用MOD方案治疗 ;VAD组 (对照组 ) 2 1例 ,采用VAD方案治疗 ,观察疗效及毒性反应。结果 :总有效率 (CR +PR)MOD组为 6 8 2 % ,VAD组为4 7 6 % ,MOD组高于VAD组 ,但差异无显著意义。两组间各种主要疗效指标比较 ,MOD组明显优于VAD ,MOD组骨髓抑制发生率明显高于VAD组 ,P <0 0 5 ,但加用G CSF后 ,均在停药 2周左右恢复 ,未见永久性造血干细胞损伤 ,髓外副作用轻微。结论 :MOD方案治疗难治性、复发性MM疗效可靠 ,副作用可以耐受 ,是目前治疗MM较理想的方法之一 ,值得临床推广应用更多还原

【Abstract】 Objective To study the effect and toxicity of MOD regimen in treatment of refractory or recurrent multiple myeloma (MM).Methods Forty three patients with refractory or recurrent multiple myeloma were randomizedly treated with MOD (curative group, 22 pts) or VAD regimen (control group,21 pts).The effect and toxicity were observed.Results The overall response rates in the groups treated with MOD or VAD regimen were 68 2% and 47 6%, respectively.The effect of MOD regimen was superior to that of VAD regimen though no statistic significance was observed.Compared with the main index of curative effect MOD regimen was superior to VAD regimen,but no statistic significance was found.Bone marrow suppression occurrence rate was higher in MOD group than that in VAD group, P <0 05.The bone marrow growth recovered within 2 weeks,with G CSF application, P <0 05. No permanent hematopoietic stem cell damage and only mildextra hematologic side effect were observed.Conclusion The MOD regimen is effective and well tolerated in the treatment of refractory or recurrent multiple myeloma and can be recommended as an optimal regimen for clinical use.更多还原